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At the time I began using this serum on human patients medicine buddha mantra leflunomide 20 mg order visa, I had no other hope than that it might accelerate the healing of surgical wounds 7r medications 10 mg leflunomide. There are millions of women in the middle age group who have held down jobs for twenty years or more who suddenly meet the competition of younger people despite their experience and competence medicine you cant take with grapefruit order leflunomide mastercard. Many of them have come for surgical help to remove the signs of age from their eyelids and face to make them look younger and hold onto their jobs for another ten years. What I had not anticipated, however, was the number of patients who received the serum and returned several months later to report that they felt younger, had more pep and energy, and that some of their aches and pains had disappeared. To prove anything, numerous experiments would have to be made under control conditions and scientific obser- vation. How Your Thoughts, Attitudes and Emotions Act as Nonspecific Therapy I began to look for other factors, or common denomina- tors, which might explain why the surgical wounds of • some patients heal faster than others. Frustration and emotional stress can be induced in mice, however, by immobilizing them so that they cannot have freedom of movement. Laboratory experiments have shown that under the emotional stress of frustration, very minor wounds may heal faster, but any real injury is made worse, and healing sometimes made impossible. How the Failure Mechanism Injures You Thus it might be said that frustration, and emotional stress (those factors we have previously described as the "failure mechanism") literally "add insult to injury" whenever the physical body suffers damage. If the physi- cal damage is very slight, some emotional stress may stimulate the defense mechanism into activity, but if there is any real or actual physical injury, emotional stress "adds to" and makes it worse. If "aging" is brought about by a "using up" of our adaptation energy, as most experts in the field seem to think, then our indulging ourselves in the negative components of the "Failure Mechanism" can literally make us old before our time. Philosophers have long told us, and now medical researchers confirm, that resentment and hatred hurt us more than the person we direct them against. There was, however, one easily recognizable characteristic which all the "rapid- healers" had in common. They were optimistic, cheerful "positive thinkers" who not only expected to "get well" in a hurry, but invari- ably had some compelling reason or need to get well quick. They had "something to look forward to" and not only "something to live for" but "something to get well for. In short, they epitomized those characteristics and atti- tudes which I have previously described as the "Success Mechanism. Lieb adds, "Tests have been made of the effect of personality disturbances on convalescence: one hospital showed that the average duration of hospitalization was increased by forty per cent from this cause. Is our Success Mechanism a sort of built-in youth serum which we can use for more life, more energy? Placebos, or "sugar pills" (capsules containing inert ingredients) have long been a medical mystery. Yet, when placebos are given to a control group in order to test the effectiveness bf a new drug, the group receiving the phony pills nearly always shows some improvement, and quite often as much as the group receiving the medicine. In 1946 the New York Journal of Medicine carried an account of a round-table discussion of placebos by mem- bers of the Department of Pharmacology and Medicine of Cornell University Medical College. Group 2 received sugar pills, and only 13 per cent suffered from seasickness, while 30 per cent of Group 3, which received nothing, got sick. Many doctors now believe that a similar type of "sug- gestive treatment" is the best form of therapy for warts. The warts are painted with methalene blue, red ink, or any other color, and a colored light is used to "treat" them. The Journal of the American Medical Association has said, "The facts of the suggestive therapy of warts seem to make a strong case in favor of the reality of such a process. They believe they are receiving legitimate medi- cine which will "bring about a cure. We may do something very similar, but in reverse, when we unconsciously "expect to get old" at a certain age. It is a matter of common observation that some people between the ages of 40 and 50 begin to both look and act "old," while others continue to act and look "young.

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A further minimum requirement is the knowledge of 200 words per semester announced on the first week symptoms 0f ms cheap leflunomide generic. There is a (written or oral) word quiz in the first 5-10 minutes of the class symptoms uric acid purchase leflunomide in united states online, every week symptoms walking pneumonia leflunomide 10 mg buy line. If a student has 5 or more failed or missed word quizzes he/she has to take a vocabulary exam that includes all 200 words along with the oral exam. The oral exam consists of a role-play randomly chosen from a list of situations announced in the beginning of the course. The result of the oral exam is added to the average of the mid-term and end-term tests. Based on the final score the grades are given according to the following table: Final score Grade 0 - 59 fail (1) 60-69 pass (2) 70-79 satisfactory (3) 80-89 good (4) 90-100 excellent (5) If the final score is below 60, the student once can take an oral remedial exam covering the whole semester’s material. Consultation classes In each language course once a week students may attend a consultation class with one of the teachers of that subject in which they can ask their questions and ask for further explanations of the material covered in that week. Website: Vocabulary minimum lists and further details are available on the website of the Department of Foreign Languages: ilekt. Introduction, immunology and other Seminar: Methods based on primary interaction of antigen disciplines2. Effector mechanisms of innate immunity 7th week: Seminar: Cells and molecules involved in immune Lecture: 25. Characteristics of acquired immunity, clonal immunoblot, immunohisto-chemistry, fluorescence selection theory6. Circulation of the lymph, antigen recognition sites in the immune system 8th week: Seminar: Characteristics of antigens and pathogens, Lecture: 29. Genetic background of the variability of Practical: Characterization of immune competent cells by antigen recognizing receptors10. Antigen-independent cell surface markers, isolation and separation of immune development of B-lymphocytes 11. Molecular basis of Self Control Test antigen recognition by B-cells and antibodies Seminar: Characteristics and effector functions of 9th week: antibodies, application of antibodies for immunological Lecture: 33. Activation of B-lymphocytes, development Practical: Functional study of immune competent cells, and function of antibody isotypes 14. Molecular basis of antigen recognition by T- The immunological aspects of bone marrow cells18. Students can make up for a missed seminar or practice with another group only within the same week. The Department is going to schedule three dates for "A" exams within the first third of the exam period. Physician - Practical: Thorax and respiratory system: inspection, medical staff relationship. Auscultation: bronchial, and the compulsory questions bronchovesicular, vesicular, tubular respiration. Rales (crepitant, sonorous, clicking, coarse, fine, subcrepitant, 2nd week: medium, bubbling, noist, dry). General symptoms Practical: Thorax and respiratory system: inspection, and the compulsory questions. Percussion of cardiac Practical: Inspection, palpation, percussion, auscultation: dullness. Practical: Physical examination of the heart (inspection, 12th week: palpation, percussion, auscultation). Percussion of cardiac Lecture: Haematological disorders: history taking and dullness. Clinical signs of cardiac Practical: Case histories (2-3 students/case), file failure (left and right ventricular failure). Practical: Case histories (2-3 students/case), file Practical: Abdominal examination (inspection, palpation, preparation with special focus of learned skills. Practical: Abdominal examination (inspection, palpation, 15th week: percussion, topography). Year, Semester: 3rd year/1 semesterst Number of teaching hours: Lecture: 30 Practical: 14 1st week: Lecture: 1. Introduction: pathobiochemistry, clinical 4th week: biochemistry, laboratory diagnostics. Pathobiochemical alterations in association laboratory diagnostics (reference values, requesting test, with tumor growth and metastasis formation and their interpretation of result).

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The immune response induced by Ad vectors treatment 2 stroke leflunomide 10 mg buy on line, although a major disadvantage medicine 2015 10 mg leflunomide purchase with amex, is also being considered as a possible advantage for transduction of tumor cells with cytokines symptoms 9 days before period buy leflunomide from india, co-stimulatory molecules, or other immune modulators in cancer vaccine protocols (see Chapter 13). These applications, thoroughly investigated in solid tumor animal models, are also being applied to hematologic malignancies such as leukemias and lymphomas. Normal primitive hematopoietic cells can be transduced by Ad, but only with very highly concentrated vector preparations that also result in significant toxicity. Transient expression in primitive cells may be of interest in manipulating homing after transplantation. The advantages of nonviral vectors include the lack of any risk of generation of replication-competent infectious particles, independence from target cell cycling during transduction, and elimination of antivector immune response induced by viral proteins. However, transduction efficiency of primary cells is very low, and physical methods such as electroporation or chemical shock used to increase gene transfer efficiency of plasmids into cell lines are either inefficient or toxic. Encapsulation by lipsomes has been useful for some primary cell types, as has conjugation to molecular conjugates including polyamines and inacti- vated adenovirus. However, none of these nonviral methods has shown any promise in the transduction of hematopoietic stem or progenitor cells. None of these vectors integrate, and expression levels are generally lower than reported with viral vectors. Less obvious are the application to tissue macrophages, dendritic cells, and central nervous system microglial cells (Chapter 9). Lineage-specific control ele- ments need to be included to allow for differential expression in the appropriate mature cell type; for example, the use of hemoglobin gene enhancers to target expression to red blood cells. The genetic correction of these cells offer a potential curative, one-time therapy for a wide variety of congenital disorders such as hemoglobinopathies, immunodeficiencies, or metabolic storage diseases. The discovery and isolation of hematopoietic cytokines in the mid-1980s allowed successful ex vivo culture and transduction, resulting in the first successful demonstration of efficient gene transfer into murine repopulating stem cells. An additional obstacle is the observation that the most primitive pluripotent hematopoietic cells appear to be predominantly in the quiescent G0 phase of the cell cycle. Attempts to increase cycling of primitive cells during transduction by prolonged culture in the presence of various combina- tions of hematopoietic cytokines has resulted in decreased engrafting ability. This is due to either loss of self-renewal properties, induction of apoptosis, or alteration in homing ability. Additionally, a characteristic of primative hematopoietic stem and progenitor cells that inhibits efficient gene transfer is the low level of expression of receptors for a number of vectors including retroviruses and adenoassociated viruses. Lastly, many clinical applications are in nonmalignant disease where the use of high-dose ablative conditioning therapy prior to reinfusion of genetically cor- rected autologous stem cells is unacceptably toxic. Only with the use of high doses of stem cells can significant levels of engraftment occur without the use of high-dose conditioning chemotherapy or total body irradiation. Preclinical Studies Initial retroviral gene transfer into murine hematopoietic repopulating cells was achieved in 1984. The discovery, availability, and application of various hematopoi- etic growth factors improved the efficiency of ex vivo retroviral transduction of murine hematopoietic cells. Several different combinations of growth factors have been successfully used for supporting gene transfer into murine stem cells. These cytokines and growth factors maintain primitive cell physiology ex vivo and poten- tially stimulate primitive cells to cycle without differentiation. Other manipulations that have been found beneficial in the murine system include (1) treatment of animals with 5-fluorouracil before marrow harvest to stimulate cycling of primitive cells, (2) the co-culture of target cells directly on a layer of retroviral producer cells or other stromal support, 5 (3) the use of high titer (greater than 10 viral particles per ml) vector and (4) co- localization of vector and target cells using fibronectin-coated dishes. The persistence of vector sequences in short-lived granulocytes and in multiple-lineage hematopoietic cells from serially transplanted mice indicates that murine repopulating stem cells can be successfully modified with retroviral vectors. Other supportive data include retroviral integration site analysis docu- menting the common transduced clones from different lineages. These results in the murine model have raised concerns about long-term expres- sion of transgenes from integrated vectors. Studies have shown poor or decreasing in vivo expression of the transgene or transgenes, especially with serial transplants, despite persistence of vector sequences. A hypothesis for this down-regulation in expression is the methylation of specific sequences in the vector promoter and enhancer regions. Using similar optimized conditions to the murine model, 50% or more progenitor colonies were transduced by retroviral vectors. These enriched progenitor cells have reconstituting properties in clinical transplantation protocols. As data emerge suggesting that the use of in vitro surrogate assays do not predict levels of gene transfer seen in vivo in early human clinical trials, attention has refo- cused on studying in vivo repopulating cells.

An R afer the component name means that it is required in the citation; an O afer the name means it is optional symptoms 0f food poisoning purchase leflunomide 10 mg on line. Author (R) | Title (R) | Content Type (O) | Type of Medium (R) | Place of Publication (R) | Publisher (R) | Date of Publication (R) | Pagination (O) | Physical Description (O) | Language (R) | Notes (O) Author for a Dissertation or Thesis (required) General Rules for Author • List names in the order they appear in the text • Enter surname (family or last name) frst for each author • Capitalize surnames and enter spaces within surnames as they appear in the document cited on the assumption that the author approved the form used medicine prescription drugs generic leflunomide 10 mg with mastercard. Tis rule ignores some conventions used in non-English languages to simplify rules for English-language publications treatment of strep throat leflunomide 10 mg order fast delivery. Names in non-roman alphabets (Cyrillic, Greek, Arabic, Hebrew, Korean) or character-based languages (Chinese, Japanese). Romanization, a form of transliteration, means using the roman (Latin) alphabet to represent the letters or characters of another alphabet. Tis rule ignores some conventions used in non-English languages to simplify rules for English-language publications. Separate the surname from the given name or initials by a comma; follow initials with a period; separate successive names by a semicolon. Dissertation or thesis with authors showing designations of rank within the family Title for a Dissertation or Thesis (required) General Rules for Title • Enter the title of a dissertation or thesis as it appears in the original document and in the original language • Capitalize only the frst word of a title, proper nouns, proper adjectives, acronyms, and initialisms • Use a colon followed by a space to separate a title from a subtitle, unless another form of punctuation (such as a question mark, period, or an exclamation point) is already present • Follow non-English titles with a translation whenever possible; place the translation in square brackets • End a title with a period unless a question mark or exclamation point already ends it or a Content Type or Type of Medium follows it, then end with a space Specific Rules for Title • Titles not in English • Titles containing a Greek letter, chemical formula, or another special character 462 Citing Medicine Box 8. Tis rule ignores some conventions used in non-English languages to simplify rules for English-language publications. Dissertation or thesis with titles containing a chemical formula, Greek letter, or other special characters 8. Musical pathology in the nineteenth century: Richard Wagner and degeneration [dissertation]. Parametros predictivos de complicaciones macroangiopaticos en la diabetes mellitus tipo 2 que precisa insulinoterapia [Predictive parameters for macroangiopathy complications in Type 2 diabetes which requires insulin] [dissertation]. Dissertation or thesis in a microform Type of Medium for a Dissertation or Thesis (required) General Rules for Type of Medium • Indicate the specifc type of medium (microfche, ultrafche, microflm, microcard, etc. Do rural Medicare patients have diferent post-acute service patterns than their non-rural counterparts? Der Anatom Eduard Jacobshagen (1886-1967) [Te anatomist Eduard Jacobshagen (1886-1967)] [dissertation on microfche]. Tis rule ignores some conventions used in non-English languages to simplify rules for English-language publications. Dissertation or thesis with place of publication not found on title page Publisher for a Dissertation or Thesis (required) General Rules for Publisher • Te publisher is the university or other institution granting the degree • Record the name of the institution as it appears in the publication, using whatever capitalization and punctuation is found there • Abbreviate well-known words in institutional names, such as Univ. If you abbreviate a word in one reference in a list of references, abbreviate the same word in all references. Place all translated publisher names in square brackets unless the translation is given in the publication. Akita (Japan): Akita Daigaku; or Akita (Japan): [Akita University]; • Ignore diacritics, accents, and special characters in names. Tis rule ignores some conventions used in non-English languages to simplify rules for English-language publications. Rousse (Bulgaria): Rusenski Universitet [Rousse University]; • If the name of a division of other part of an organization is included in the publisher information, give the names in hierarchical order from highest to lowest Valencia (Spain): Universidade de Valencia, Instituto de Historia de la Ciencia y Documentacion Lopez Pinero; • As an option, you may translate all publisher names not in English. Place all translated publisher names in square brackets unless the translation is given in the publication. Dissertation or thesis publisher with subsidiary part included 472 Citing Medicine 13. Dissertation or thesis issued by other than a university Date of Publication for a Dissertation or Thesis (required) General Rules for Date of Publication • Always give the year of publication, i. Studies of fall risk and bone morphology in older women with low bone mass [dissertation]. Studies of fall risk and bone morphology in older women with low bone mass [dissertation]. Dissertation or thesis date with season Pagination for a Dissertation or Thesis (optional) General Rules for Pagination • Provide the total number of pages on which the text of the dissertation or thesis appears • Do not count pages for such items as introductory material, appendixes, and indexes unless they are included in the pagination of the text • Follow the page total with a space and the letter p • For dissertations or theses published in more than one physical volume, cite the total number of volumes instead of the number of pages, such as 2 vol • End pagination information with a period 474 Citing Medicine Specific Rules for Pagination • No numbers appear on the pages Box 21. If the entire publication has no page numbers: • Count the total number of pages of the text • Express the total as leaves, not pages • End with a period Example: 37 leaves. Dissertation or thesis submitted in more than one volume Physical Description for a Dissertation or Thesis (optional) General Rules for Physical Description • Give information on the physical characteristics if a dissertation or thesis is published in a microform (microflm, microfche, microcard, etc. Specific Rules for Physical Description • Language for describing physical characteristics Box 22.

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Musan, 21 years: All of them were divided into 3 small groups each belonging equal number of both male and female sex. Seik-phoo was found to possessed marked anti-diarrheal effect comparable to loparpmide, as seen by a significant delay in onset on diarrhea in first hour and a market reduction in the number of diarrhea stools (12. The ‘achievement of potential for self-realisation’ reflects the process, and ‘organised services’ reflect assistance towards that process. In practice, the four- parameter form is usually selected as a general model of assay response.

Pavel, 29 years: This material should be removed by curettage and flushing, cultured for bacteria and fungus, and the ear treated with appropriate topical and systemic antibiotics. To prevent regaining weight, dieters must stick to this level of carbohydrate consumption, perhaps for the rest of their lives. Aims of the course: To teach the molecular and morphological aspects of clinical neurosciences and to provide a solid basis for the clinical studies and medical practice. Autogenous medullary bone (collected from the tibio- tarsus), corticocancellous bone (collected from the sternum or ribs) and cortical bone (devitalized frag- ments from the fracture site) have been shown to augment bone healing in birds.

Darmok, 35 years: The men received a supplement of zinc sulfate (60 mg elemental zinc per day) for 45 to 50 days. Coated tubes closed under nitrogen atmosphere and stored at - 20° С could be used for at least three months whereas open tubes had a shorter shelf-life. Figure 3, Infuence of seed extract of Syzygium Cumini (Jamun) on mice exposed to diferent doses of γ-radiation; p. Citation Rules with Examples for Journal Articles Components/elements are listed in the order they should appear in a reference.

Finley, 31 years: The choanae are separated into right pronounced in gallinaceous species but are also and left openings by the nasal septum or vomer bone. To achieve health in this sense could therefore be considered a justification for rehabilitation as assistance. Renal resistive index better predicts the occurrence of acute kidney injury than cystatin C. Then, your response will be appropriate—and you will have no time to notice or respond to a fictitious environ- ment.

Grompel, 45 years: However, the presence of the cable limits the length of the subject displacement and could sometimes interfere with his movement. Exception is if using Newspaper Articles 613 a volume and issue in place of a section (see Optional volume and issue numbers used instead of section information below). The isolated compounds were identified by column and thin layer chromatography using benzene, ethyl acetate methanol (2:2:1v/v). Dutch uitgave Uitg editie Ed Finnish julkaisu Julk French edition Ed German Ausgabe Ausg Greek ekdosis Ekd Italian edizione Ed Norwegian publikasjon Publ Portuguese edicao Ed Russian izdanie Izd Spanish edicion Ed Swedish upplaga n.

Abe, 59 years: An implication of the story is that this research breakthrough will speedily trans- form, in the next few years, into a marvelous new therapy in molecular genetic medicine. However, much training involves acquiring theoretical knowledge that makes up most of the curriculum, and this objective can be accomplished equally through either traditional or e-learning arrangements. Most affected birds die during the bacteremic fecal examinations of all new additions during the phase of an infection. Localized infections may children of elementary school age are particularly occur in the upper respiratory tract, causing rhinitis, susceptible to infections.

Giacomo, 64 years: One photo about a slide (with different magnifications) has to be described and diagnosed (from the whole year). After 24 hours, the group that received the magnesium had an average heart rate of roughly 80, while the group that received only digoxin had an average heart rate of 105. The experienced avicultur- cent carbaryl powder has been used successfully ist should know how to administer stabilizing ther- without apparent harm to chicks or adults. One of the most common ways this is done is to give providers monetary rewards for limiting referrals to specialty providers.

Randall, 51 years: All allergens, wheat, corn, and dairy products, and carrageenan-containing foods should be eliminated. Therefore, extensive genetic reprogramming of donor nuclei was possible but required serial nuclear transplantation similar to that used in amphibia. Crushed shell will provide a source of calcium, and is not effective in aiding in the mechani- cal breakdown of dietary plant material. Unfortunately, the two clinical trials conducted to date failed to show any benefit.

Rendell, 46 years: American Academy of Pediatrics, Committee on Pediatric Emergency Medicine; American College of Emergency Physicians, Pediatric Committee. Proceedings of the International Conference on Inclusive Design; 2005 Apr 5-8; London. You do not need to be an electronic engineer, or a physicist, to operate your own servo-mechanism, any more than you have to be able to engineer an automobile in order to drive one, or become an electrical engineer in order to turn on the light in your room. In case of a b n o rm a lities, a "route map" in the docum entation shows the sequence in which a lte r n a tiv e p la u sib le prompts w ill be made.

Jaffar, 40 years: Your legs begin to collapse and continue until they consist only of deflated rubber tubes, lying flat against the bed. Selective brain hypothermia using different devices has therefore been proposed [49–52]. Any new knowledge must usually come from the outside—not from "experts," but from what someone has defined as an "inpert. Given the high number of birds with anti- often fatal illness in young birds or with nonhost- bodies to chlamydia, most primary infections must adapted chlamydial strains.

Volkar, 47 years: For publications with joint or co-publishers, use the name given frst as the publisher and include the name of the second as a note if desired. It appears that as some people age, they lose the ability to manufacture sufficient levels of glucosamine. Nonviral Vectors Liposomes Liposomes are microscopic vesicles consisting of one or multiple aqueous compartments. Methanol extract and total alkaloid extract of stems of two selected plants were examined their antimicrobial activity on eight bacteria species (Escherichia coli, Klebsiella pneumoneae, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella paratyphi, Shigella dysentery (Type1), Staphylococcus aureus and Streptococcus pyogenes).

Karrypto, 54 years: Proceedings of the 3rd International Conference on Gastroenterology Surgery; 2004 May 3-5; Bonn, Germany. Your right to use the work may be ter- minated if you fail to comply with these terms. In a very preliminary study on pigs, we addressed cerebral microcirculatory Àows in relation to carotid blood Àows. In the event of a decision to release the resident from further patient care activity; notification of program and administrative personnel shall include the chief/supervising resident on-call, program director and department chair, respectively, depending on the ability to contact these individuals.

Jaroll, 36 years: Internet journal title with other division to date than month or season 1606 Citing Medicine Date of Citation for Journal Titles on the Internet (required) General Rules for Date of Citation • Give the date the journal was seen on the Internet • Include the year month and day in that order, such as 2006 May 5 • Use English names for months and abbreviate them using the frst three letters, such as Jan • Place citation date information in square brackets • End date information with a period placed outside the closing bracket Examples for Date of Citation 1. It has been found that the ionic strength of the immobilization mixture does not have much influence on the degree of antibody adsorption in the scope of our study, in contradiction to the literature [22]. Such cells can be engineered ex vivo and applied alone or with cytokines, which have also been engineered into the tumor cells or into a carrier cell co-administered with the tumor cell vaccine. The severity of liver involvement is variable, ranging from moderate iso- lated hepatic transaminase elevations to fulminant liver failure with encephalopathy [25].

Ivan, 53 years: This observed low incidence of mutagenesis indicates that the retroviral vector is unlikely to integrate into a genomic site that will modify cellular growth properties such as cyclins- or cyclin-dependent kinases (see Chapter 10). Comparative efficacy of a single daily dose of two capsules of Cyclo 3 Fort in the morning versus a repeated dose of one capsule morning and noon. Note that the cloaca is being compressed and the colon is oriented in a cranial, provide easily digested carbohydrate (eg, canary rather than its normal right lateral position (open arrow). A failure to attend to give evidence could be a breach of such duty, but it is not the duty itself.

Kalesch, 23 years: Radiographs indicated a large may originate in the pulmonary pa- mass that had invaded the synsacrum and was displacing the cloaca ventrally. Egg-related of medroxyprogesterone varies with the size of the pancreatitis may cause temporary diabetes mellitus, bird (150 g [0. Diet Avoid coffee, alcohol, hot beverages, spicy foods, and any other food or drink that causes a flush. Pilot study on the effects of high cutoff hemofiltration on the need for norepinephrine in septic patients with acute renal failure.

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